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A New Model for Short Bowel Syndrome

Thursday, July 23, 2020   (0 Comments)
Posted by: Andrea Guidi
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WASHINGTONJuly 22, 2020 /PRNewswire/ -- An article published in Experimental Biology and Medicine (Volume 245, Issue 12, June 2020)

(https://journals.sagepub.com/doi/pdf/10.1177/1535370220915881describes a new animal model for short bowel syndrome. The study, led by Dr. Ajay Jain in the Department of Pediatrics at the St. Louis University School of Medicine in St. Louis, MO, (USA), reports that a validated piglet model recapitulates the anatomical, histological and serological characteristics observed in humans with short bowel syndrome.

In cases where the intestines are sick or damaged, surgical removal of a large portion of bowel may be necessary. However, this may result in a condition known as short bowel syndrome (SBS). Individuals with SBS are unable to tolerate food or absorb essential nutrients through the gastrointestinal tract, and require delivery of fluid and nutritional needs intravenously, a process called total parenteral nutrition (TPN). Although TPN has proven to be lifesaving in SBS, it does have significant side effects including injury to the liver and the remaining intestine. Unfortunately, the reason for this injury is not fully known. Novel ambulatory animal models that recapitulate human SBS are needed to fully understand the disease process and side effects of TPN delivery, as well as develop new therapies that will improve patient outcomes.   

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This website was updated in 2015 with a generous grant from Shire, Inc. This website is an educational resource. It is not intended to provide medical advice or recommend a course of treatment. You should discuss all issues, ideas, suggestions, etc. with your clinician prior to use. Clinicians in a relevant field have reviewed the medical information; however, the Oley Foundation does not guarantee the accuracy of the information presented, and is not liable if information is incorrect or incomplete. If you have questions please contact Oley staff.
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