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Short bowel, short answer?
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J. Nightingale, Department of Gastroenterology, Leicester Royal Infirmary

 

Patients with short bowel syndrome or intestinal damage (e.g. from ischaemia, irradiation, necrotising enterocolitis etc,) will be interested to know that new information has been released on GLP-2, a growth hormone which may promote bowel adaptation. GLP-2 has been used to promote villus/crypt growth in the small and large bowel and to increase the length and weight of the small and large bowel in mice. New research by Jeppesen et al published in the October, 1999 issue of Gut shows that GLP-2 concentrations are low in patients with an end jejunostomy (lacking an ileum and colon). This may explain why these patients show less evidence of structural or functional intestinal adaptation over time. In his summary of Jeppesen’s research, J. Nightingale suggests that GLP-2 may be given to patients with short bowel syndrome or intestinal damage to promote adaptation in the future. At present, GLP-2 is in the research stage of development.

 

Click here to read Nightingale’s summary of the GLP-2 Research
Click here to read Jeppesen’s research article

 

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This website is an educational resource. It is not intended to provide medical advice or recommend a course of treatment. You should discuss all issues, ideas, suggestions, etc. with your clinician prior to use. Clinicians in a relevant field have reviewed the medical information; however, the Oley Foundation does not guarantee the accuracy of the information presented, and is not liable if information is incorrect or incomplete. If you have questions please contact Oley staff.

 

Updated in 2015 with a generous grant from Shire, Inc. 

 

This website was updated in 2015 with a generous grant from Shire, Inc. This website is an educational resource. It is not intended to provide medical advice or recommend a course of treatment. You should discuss all issues, ideas, suggestions, etc. with your clinician prior to use. Clinicians in a relevant field have reviewed the medical information; however, the Oley Foundation does not guarantee the accuracy of the information presented, and is not liable if information is incorrect or incomplete. If you have questions please contact Oley staff.
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